ADC Release and Stability Testing
ADC release and stability testing built for conjugates rather than adapted from antibody methods. We measure DAR distribution, free payload, aggregation and conjugate integrity across storage and stress conditions, so instability is caught before it reaches a clinical batch.
OVERVIEW
Our capabilities include the following assays:
- Antigen binding activity determination: ELISA, FACS
- Drug to Antibody ratio (DAR) determination: UV-Vis, LC-MS, HPLC-HIC, iCIEF, etc.
- Residues of free drug determination: LC-MS/MS
- In vitro efficacy and bioactivity determination: Cytotoxicity assay
