Mixed Lymphocyte Reaction (MLR) Assay
Mechanism of action studies that establish target engagement rather than infer it. We combine cellular target engagement, pathway readouts and selectivity profiling to show what your compound does inside a cell — and, just as usefully, what it does not do.
OVERVIEW
Everything a sponsor evaluating an outsourced biologics CMC partner needs to know — from capacity to compliance.
The MLR assay is considered the ‘gold standard’ T cell functional assay for the test of T cell immune checkpoint inhibitors
- Dendritic cells co-cultured with allogeneic CD3+ T cells
- Readouts: IFN-γ and IL-2 production
- Suitable to test both antibodies and small molecules, as single agents and in combination
